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five–4 μmol/L range,[156][157] the concentration of serotonin in synaptic vesicles was calculated at 270 mM.[182] next vesicular release, the ensuing focus of serotonin while in the synaptic cleft, to which serotonin receptors are uncovered, is estimated to generally be about three hundred μmol/L. Thus, even though in vitro receptor binding a
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